By Kasugai, Yu; Machtoub, Lina
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Extra resources for Amyotrophic lateral sclerosis : advances and perspectives of neuro-nanomedicine
Clinical examinations should be repeated at least every six months to assess progression. machtoub–ALS October 23, 2015 12:42 PSP Book - 9in x 6in Clinical Features in the Diagnosis of ALS Cases which meet the topographical criteria for probable or deﬁnite ALS but which lack progression during the 12-month period diagnosis should be designated as possible ALS. Deﬁnite ALS is deﬁned on clinical grounds alone by the presence of UMN as well as LMN signs in the bulbar region and at least two of the other spinal regions or the presence of UMN and LMN signs in three spinal regions.
J Neurol Sci 1994;124(suppl):98–107. 6. Saito Y, Yokota T, Mitani T, et al. Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model. J Biol Chem 2005;280:42826–42830. 7. Wolfson C, Kilborn S, Oskoui M, Genge A. Incidence of amyotrophic lateral sclerosis in Canada. Neuroepidemiology 2009;33:79–88. 8. Chio A, Mora G, Calvo A, et al. Epidemiology of ALS in Italy: a 10-year prospective population-based study. Neurology 2009;24:725–731. 9. Nishimura AL, Mitne-Neto M, Silva HC, et al.
The main use of MRI is to rule out other conditions that can mimic, or appear very similar to, ALS. These include compression of the spinal cord from a slipped disc or fracture of the spine, as well as strokes and multiple sclerosis. Unlike with these other conditions, an MRI scan appears normal in a person with ALS. Conventional MR imaging ﬁndings Routine anatomic imaging of the brain and/or the spinal cord is helpful in ruling out diseases that mimic ALS with varying degrees of UMN and LMN signs.