Alzheimer's Disease: Advances in Genetics, Molecular and by Sangram S. Sisodia, Rudolph E. Tanzi

By Sangram S. Sisodia, Rudolph E. Tanzi

This e-book examines each significant element of Alzheimer ailment at a time while there was no scholarly study quantity at the topic released within the final 3-5 years. This version contains elevated assurance of the cellular-level exploration of similar dementing issues, with in-depth presentation of prion ailments, Pick's sickness, fronto-temporal issues, transgenic versions, and biochemistry of presenilins.

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Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS (2005) J Neurosci 25:2386–2395. Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM (2005) J Cell Biol 168:291–302. Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH (2003) J Cell Biol 163:83–95. Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GT, Luyendijk W, Frangione B (1990) Science 248:1124–1126.

Furthermore, it is difficult to separate the cell adhesive from the neurite 2. APP Biology, Processing and Function 29 outgrowth promoting roles of APP. Clearly, these are probably somewhat inseparable, as neuronal migration, neurite outgrowth, and even synaptogenesis would involve substrate adhesion. The phenotype of APP and APLP-deficient animals are certainly in agreement with these proposed physiological activity of these molecules (see below). 3 Is APP a receptor? Although APP was initially proposed to act as a cell surface receptor, the evidence supporting this idea has been unconvincing.

Thinakaran G, Parent AT (2004) Pharmacol Res 50:411–418. Torroja L, Chu H, Kotovsky I, White K (1999) Curr Biol 9:489–492. Vassar R (2004) J Mol Neurosci 23:105–114. Vetrivel, KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G (2005) J Biol Chem 280:25892–25900. Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G (2004) J Biol Chem 279:44945–44954. von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS (1997) Neurobiol Aging 18:661–669.

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