Ageing Vulnerability: Causes and Interventions - No. 235 by Novartis Foundation

By Novartis Foundation

With the ever-increasing upward thrust in existence expectancy, there's an pressing have to enhance our figuring out of the connection among getting old and the pathogenesis of age-related illnesses on the way to determine more advantageous technique of prevention, amelioration and administration of such illnesses. moreover, there's a have to lessen the social and fiscal effect of the aging inhabitants. Age-related morbidity and mortality vary dramatically between participants; this booklet focusses on person modifications in susceptibility to age-related issues.

It includes contributions from best specialists within the box on subject matters such as:
age-related pathology within the mind, age-related techniques in stem cells, and age-related results at the immune method and in bone, muscle and cardiovascular tissue.

For all people with an curiosity within the biology of growing older, this can be obligatory reading.

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Bush: We do use them up. This is where the protein slowly oligomerizes. It appears that the donating groups are methionine and tyrosine, and possibly also histidine. The molecule in fact o¡ers lots of electrons. We are just trying to ¢gure out which residues go ¢rst and which are the most important. Halliwell: Suppose it is tyrosine, and you make tyrosine radicals that dimerize. g. with glutathione. What happens in your system if you put in biological reducing agents such as ascorbate and glutathione?

There seems to be an interesting connection between antioxidant status, both in the brain and in other parts of the body as represented by the lymphocytes, that might provide a way of extending the relevance of the amyloid story to other cells. Bush: That whole system is very intriguing. I would imagine that Ab’s activity is ubiquitous. I think its role in terms of oxidation in general, however, is subtle. It is very specialized in the brain, where it might be that the microenvironment makes it liable to become damaged.

The problem with GSH is that it is a charged compound, since it contains cysteine. It is unlikely to cross the blood^brain barrier very e¡ectively. There are ester forms that could be used, but in the clinical study I mentioned they were using GSH. We did repeated systemic injections with buthionine sulfoxamine (BSO), which is an inhibitor of GCS, in order to look at the e¡ects of lowering GSH levels in the brain. We found that you have to do repeated injections in order to get enough BSO across that blood^brain barrier to have an e¡ect.

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