Advances in Alzheimer's and Parkinson's Disease: Insights, by Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel

By Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin

This quantity comprises the court cases of the 2005 ADPD convention and is exclusive in that it offers not just with concerns similar separately to Alzheimer’s illness and Parkinson’s affliction, but in addition with the combination of those and different similar illnesses. the main updated strategies and learn findings are illustrated during this quantity, which overlaying themes from immunology, neuroscience, and pharmacology to genetics and molecular biology. attainable destiny advancements within the remedy of Alzheimer’s and Parkinson’s illnesses also are covered.

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53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. Chapter 3 Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity Simona Francisconi, Mara Codenotti, Erminia Poli, Daniela Uberti, Giulia Ferrari-Toninelli, and Maurizio Memo Introduction Preservation of genomic stability is an essential biological function, and cells engage efficient mechanisms to maintain DNA stability over time and prevent the generation and the persistence of impaired cells that may be detrimental to the organism.

Msh2þ/À mice were also found to be more sensitive to KA-induced neurodegeneration in the hippocampal CA3 field. The response to KAmediated excitotoxicity includes also the induction of cyclooxygenase-2 (COX-2) expression, which parallels the appearance of neuronal apoptotic features in the same cell types affected by KA treatment. Immunohistological studies in wild-type and Msh2þ/À mice treated with KA showed that COX-2 protein expression was enhanced in the CA3 neurons of heterozygous mice compared to those in wild-type mice.

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